Bevacizumab, in addition to platinum-based chemotherapy, is indicated for first-line treatment of adult patients with unresectable advanced, metastatic or recurrent non-small cell lung cancer other than predominantly squamous cell histology. Bevacizumab, in combination with erlotinib, is indicated for first-line treatment of adult patients with unresectable advanced, metastatic or recurrent non-squamous non-small cell lung cancer with Epidermal Growth Factor Receptor EGFR activating mutations.
Bevacizumab, in combination with carboplatin and gemcitabine, is indicated for treatment of adult patients with first recurrence of platinum-sensitive epithelial ovarian, fallopian tube or primary peritoneal cancer who have not received prior therapy with bevacizumab or other VEGF inhibitors or VEGF receptor—targeted agents. Bevacizumab in combination with paclitaxel, topotecan, or pegylated liposomal doxorubicin is indicated for the treatment of adult patients with platinum-resistant recurrent epithelial ovarian, fallopian tube, or primary peritoneal cancer who received no more than two prior chemotherapy regimens and who have not received prior therapy with bevacizumab or other VEGF inhibitors or VEGF receptor—targeted agents.
Bevacizumab, in combination with paclitaxel and cisplatin or, alternatively, paclitaxel and topotecan in patients who cannot receive platinum therapy, is indicated for the treatment of adult patients with persistent, recurrent, or metastatic carcinoma of the cervix.
Please do not include any personal data , such as your name or contact details. Skip to main content. Veterinary regulatory Overview Research and development Marketing authorisation Post-authorisation. Avastin RSS. Table of contents Overview Authorisation details Product information Assessment history. Expand section Collapse section.
Avastin is used in combination with certain chemotherapy medicines in newly diagnosed patients when the cancer is advanced, or in previously treated patients whose cancer has come back recurrent. Avastin is given in combination with paclitaxel and either the platinum-based medicine cisplatin or, if this cannot be used, another chemotherapy medicine, topotecan. Cancer of the colon or rectum In metastatic cancer of the colon or rectum, Avastin used with chemotherapy including a fluoropyrimidine has been shown to increase overall and progression-free survival in three main studies.
Breast cancer In metastatic breast cancer, Avastin has been shown to increase progression-free survival in two main studies. Non-small cell lung cancer In advanced, metastatic or recurrent lung cancer, Avastin plus platinum-based chemotherapy has been shown to increase overall survival in one study in patients: the average overall survival was In patients with a certain subtype of non-small cell lung cancer with activating mutations in the EGFR gene, Avastin plus erlotinib has been shown to increase progression-free survival in one study in patients: patients on Avastin plus erlotinib had progression-free survival of Kidney cancer In advanced or metastatic kidney cancer, Avastin plus interferon alfa-2a has been shown to increase progression-free survival in one study in patients: the average progression-free survival was Ovarian, fallopian tube and peritoneal cancer Newly diagnosed disease including advanced disease, first-line treatment : in newly diagnosed ovarian, fallopian tube and peritoneal cancer, Avastin, in combination with carboplatin and paclitaxel, has been shown to increase progression-free survival in two main studies involving 3, patients: the average progression-free survival was Recurrent disease: three studies with Avastin in recurrent ovarian, fallopian tube and peritoneal cancers were performed in a total of 1, patients.
In the first study, average progression-free survival was In the second study, overall survival in patients given Avastin in combination with carboplatin and paclitaxel was In the third study in patients with more aggressive cancer, progression-free survival was 6.
Cervical cancer In cancer of the cervix, Avastin has been shown to increase overall survival in one main study involving patients with advanced persistent, recurrent or metastatic cancer of the cervix. Authorisation details. Product details Name Avastin.
Product information. List item. You are therefore advised to be selective about which sections or pages you wish to print. Antineoplastic agents. Avastin is an injectable cancer medication that works by blocking a protein that is important for the formation of blood vessels.
Since tumors rely on blood vessels to get the nutrients they need to survive, the drug is thought to work by preventing the formation of new blood vessels that feed the tumor. Avastin was first approved in for treatment of advanced colon cancer and has been approved since for advanced lung , kidney and brain glioblastoma cancers Avastin was approved for metastatic breast cancer in under the accelerated approval program.
Under the accelerated approval program, a drug may be approved based on results of clinical data that suggest the drug has an important clinical benefit.
However, additional information is needed to confirm the data. The FDA has proposed withdrawing Avastin's indication to treat women with metastatic breast cancer. Avastin is an immune targeted therapy. Avastin is given intravenously, which means the medicine is delivered directly into your bloodstream through an IV or a port. After that, it only takes about 30 minutes to an hour to get the other doses of Avastin. Avastin is usually given every 2 weeks.
These side effects can be managed, and in the case of high blood pressure, treated with standard medication.
Other possible common side effects include:. More serious side effects have been experienced in a small percentage of people taking Avastin, including blood clots in a vein, slow wound healing , perforation of the intestines, higher risk of stroke or heart problems , kidney malfunction , and reduced white blood cell count.
If you experience any of these serious side effects, your doctor will stop treatment with Avastin. Since Avastin is given with chemotherapy, you may also experience chemotherapy side effects. Create a profile for better recommendations. Breast implant illness BII is a term that some women and doctors use to refer to a wide range
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